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Information on Zebutal

Pronounced:ZEB-byoo-tal
Generic ingredients:Butalbital, Acetaminophen, Caffeine
Other Brand Names: Anolor 300, Esgic-Plus

Why is Zebutal prescribed?

Zebutal, a strong, non-narcotic pain reliever and relaxant, is prescribed for the relief of tension headache symptoms caused by muscle contractions in the head, neck, and shoulder area. It combines a sedative barbiturate (butalbital), a non-aspirin pain reliever (acetaminophen), and caffeine.

Most important fact about Zebutal

Mental and physical dependence can occur with the use of barbiturates such as butalbital when these drugs are taken in higher than recommended doses over long periods of time.

How should you take Zebutal?

Take Zebutal exactly as prescribed. Do not increase the amount you take without your doctor's approval.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

--Storage instructions...

Store at room temperature in a tight, light-resistant container.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zebutal.

More common side effects may include:

abdominal pain
dizziness
drowsiness
intoxicated feeling
light-headedness
nausea
sedation
shortness of breath
vomiting

Less common or rare side effects may include:

agitation
allergic reactions
constipation
depression
difficulty swallowing
dry mouth
earache
exaggerated feeling of well-being
excessive sweating
excessive urination
excitement
fainting
fatigue
fever
flatulence
headache
heartburn
heavy eyelids
high energy
hot spells
itching
leg pain
mental confusion
muscle fatigue
numbness
rapid heartbeat
ringing in the ears
seizure
shaky feeling
skin redness and/or peeling
sluggishness
stuffy nose
tingling

Why should Zebutal NOT be prescribed?

If you are sensitive to or have ever had an allergic reaction to barbiturates, acetaminophen, or caffeine, you should not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced.

Unless you are directed to do so by your doctor, do not take this medication if you have porphyria (an inherited metabolic disorder affecting the liver or bone marrow).

Special warnings about Zebutal

Zebutal may cause you to become drowsy or less alert; therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended until you know your response to this drug.

If you are being treated for severe depression or have a history of severe depression or drug abuse, consult with your doctor before taking Zebutal.

Use this drug with caution if you are elderly or in a weakened condition, if you have liver or kidney problems, or if you have severe abdominal trouble.

Possible food and drug interactions when taking Zebutal

Butalbital slows the central nervous system (CNS) and intensifies the effects of alcohol and other CNS depressants. Use of alcohol with this drug may also cause overdose symptoms. Avoid alcoholic beverages while taking Zebutal.

If Zebutal is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zebutal with the following:

Antihistamines such as Benadryl
Drugs known as monoamine oxidase inhibitors, including the antidepressants Nardil and Parnate
Drugs to treat depression such as Elavil
Major tranquilizers such as Haldol and Thorazine
Muscle relaxants such as Flexeril
Narcotic pain relievers such as Darvon
Sleep aids such as Halcion
Tranquilizers such as Xanax and Valium

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, inform your doctor immediately. Zebutal can affect a developing baby. It also appears in breast milk. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding your baby until your treatment is finished.

Recommended dosage

ADULTS
The usual dose of Zebutal is 1 tablet every 4 hours as needed. Do not take more than 6 tablets a day.

CHILDREN
The safety and effectiveness of Zebutal have not been established in children under 12 years of age.

OLDER ADULTS
Zebutal may cause excitement, depression, and confusion in older people. Therefore, your doctor will prescribe a dose individualized to suit your needs.

Overdosage

Symptoms of Zebutal overdose can be due to its barbiturate or its acetaminophen component.

Symptoms of barbiturate poisoning may include:

coma
confusion
drowsiness
low blood pressure
shock
slow or troubled breathing

Overdose due to the acetaminophen component of Zebutal may cause kidney and liver damage, blood disorders, or coma due to low blood sugar. Massive doses may cause liver failure.

Symptoms of liver damage include: